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Senior Manager, Clinical Supply Integration

Olema Oncology • San Francisco, CA, US • published 2026-09-30 07:58:48.930075

Description

Olema Oncology is a clinical\-stage biopharmaceutical company committed to transforming the standard of care and improving outcomes for patients living with breast cancer and beyond. With our transformation into a fully integrated oncology company well underway, it's an exciting time to be part of Team Olema. Our lead product candidate, palazestrant, is a novel, orally available complete estrogen receptor antagonist (CERAN) and selective estrogen receptor degrader (SERD) currently in two pivotal Phase 3 clinical trials. We expect top\-line data from OPERA\-01, our ongoing Phase 3 trial of palazestrant as a monotherapy in patients with second\- or third\-line ER\+/HER2\- metastatic breast cancer (MBC), in Q1 2027 which, if positive, could lead to our first potential approval and commercial launch in 2028\. OPERA\-02, our Phase 3 trial of palazestrant in combination with ribociblib in patients with frontline ER\+/HER2\- MBC, is enrolling patients. Together with its mechanism of action, pharmacokinetic properties, and the potential to demonstrate activity in both ESR1 wild\-type and mutant tumors, palazestrant could transform the metastatic breast cancer treatment paradigm and provide...

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