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Scientist, Synthetic Biology

Strand Therapeutics • Boston, MA, US • published 2026-10-08 15:04:19.986256

Description

Company Overview: Strand Therapeutics is a clinical\-stage biotechnology company pioneering programmable mRNA therapeutics to unlock the full potential of genetic medicines. Strand is applying its proprietary Signal Stack platform, which integrates EverScript circular RNA, AmpliScript self\-replicating RNA, SignalPath targeted delivery, and logic\-driven SignalLock genetic circuits to enable precise control of therapeutic activity across tissues and cell types and overcome foundational limitations in targeting, durability, and safety. Strand is advancing a pipeline with an initial focus on oncology and autoimmune disease. Its initial program, STX\-001, an intratumorally delivered LNP\-encapsulated self\-replicating RNA expressing IL\-12, has demonstrated preliminary evidence of systemic immune activation and anti\-tumor activity in patients with advanced solid tumors who have progressed on prior therapies. Building on this early clinical validation, intravenously delivered STX\-003 is designed for tumor\-targeted expression and avoidance of off\-target expression. STX\-003, which is expected to enter the clinic in mid\-2026, has the potential to be a major step forward for the fiel...

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