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Postdoctoral Research Fellow — Clonal Evolution and Genome Engineering in Inherited Bone Marrow Failure Disorders

St. Jude Children's Research Hospital • Memphis, TN, US • published 2026-10-09 09:03:26.684421

Description

Location Memphis, TN Category Postdoc Department Center for Leukemia Studies Shift Weekday Day Position Type Full Time Scheduled Weekly Hours 40 Req \# JR7851 **Job Description** ------------------- A postdoctoral research associate position is available in the lab of Alyssa Kennedy. We are recruiting a postdoctoral fellow to study the mechanisms of clonal evolution and leukemic transformation in inherited bone marrow failure syndromes, with a focus on Shwachman\-Diamond syndrome (SDS). The lab studies how somatic adaptation shapes disease trajectory, why certain clones are compensatory while others are pre\-malignant, and whether therapeutic genome editing can shift that balance. Projects span primary patient samples, iPSC cell line models, CRISPR/base\-editing screens, and single\-cell genomics, with direct access to a clinical bone marrow failure program. **Qualifications** Required: * PhD, MD, or MD/PhD (or expected within six months) in hematology, cancer biology, genetics, genome engineering, immunology, or a related field * Track record of productivity, including at least one first\-author publication (published or in press) * Hands\-on experience and expertise with molecula...

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